Publications

IZKF

Head of Department:
Prof. Dr. med. André Reis

Publications

2016

 

A. S. Link, S. Kurinna, S. Havlicek, S. Lehnert, M. Reichel, J. Kornhuber, et al., "Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling," Mol Neurobiol, vol. 53, pp. 4210-25, Aug 2016.

H. K. Mishra, I. Prots, S. Havlicek, Z. Kohl, F. Perez-Branguli, T. Boerstler, et al., "GSK3ss-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model," Ann Neurol, Mar 11 2016.

C. M. O'Tuathaigh, F. Fumagalli, L. Desbonnet, F. Perez-Branguli, G. Moloney, S. Loftus, et al., "Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 x DISC1," Schizophr Bull, Sep 9 2016.

R. Salvi, T. Steigleder, J. C. Schlachetzki, E. Waldmann, S. Schwab, B. Winner, et al., "Distinct Effects of Chronic Dopaminergic Stimulation on Hippocampal Neurogenesis and Striatal Doublecortin Expression in Adult Mice," Front Neurosci, vol. 10, p. 77, 2016.

M. Schulze, S. Hoja, B. Winner, J. Winkler, F. Edenhofer, and M. J. Riemenschneider, "Model Testing of PluriTest with Next-Generation Sequencing Data," Stem Cells Dev, vol. 25, pp. 569-71, Apr 1 2016.

A. Sommer, T. Fadler, E. Dorfmeister, A. C. Hoffmann, W. Xiang, B. Winner, et al., "Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model," J Neuroinflammation, vol. 13, p. 174, 2016.

2015

 

E. Eberhardt, S. Havlicek, D. Schmidt, A. S. Link, C. Neacsu, Z. Kohl, et al., "Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors," Stem Cell Reports, vol. 5, pp. 305-13, Sep 8 2015.

H. Y. Hawong, J. R. Patterson, B. M. Winner, J. L. Goudreau, and K. J. Lookingland, "Comparison of the structure, function and autophagic maintenance of mitochondria in nigrostriatal and tuberoinfundibular dopamine neurons," Brain Res, vol. 1622, pp. 240-51, Oct 5 2015.

A. S. Link, S. Kurinna, S. Havlicek, S. Lehnert, M. Reichel, J. Kornhuber, et al., "Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling," Mol Neurobiol, Jul 28 2015.

D. Madzar, M. Hagge, S. Moller, M. Regensburger, D. H. Lee, S. Schwab, et al., "Endogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report," BMC Res Notes, vol. 8, p. 184, 2015.

J. Park, M. Gebhardt, S. Golovchenko, F. Perez-Branguli, T. Hattori, C. Hartmann, et al., "Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage," Biol Open, vol. 4, pp. 608-21, 2015.

S. R. Schreglmann, M. Regensburger, E. Rockenstein, E. Masliah, W. Xiang, J. Winkler, et al., "The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice," PLoS One, vol. 10, p. e0126261, 2015.

B. Winner and J. Winkler, "Adult neurogenesis in neurodegenerative diseases," Cold Spring Harb Perspect Biol, vol. 7, p. a021287, Apr 2015.


2014
Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer S,Marchetto MCN, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons. HMG, 2014; 23(10):2527-41.

Franz S*, Ciatipis M*, Pfeifer K, Kierdorf B, Bogdahn U, Blesch A, Winner B, Weidner N. Thoracic rat spinal cord contusion injury induces remote spinal  gliogenesis but not neurogenesis or gliogenesis in the brain. Plos One. Accepted 7/2014. *contributed equally

Purohit P*, Perez-Branguli F*, Prots I*, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D. The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons. Plos One. Accepted 7/2014. *contributed equally

Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E; Winner B, Wegner M, Winkler J. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Molecular and Cellular Neuroscience. Accepted 6/2014.

Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-    Schrehardt U, Winkler J, Winner  B. Dysfunction of spatacsin leads to axonal pathology in SPG11 linked hereditary spastic paraplegia. HMG published online 05/2014.

May VE, Ettle B, Poehler AM, Nuber S, Ubhi K, Rockenstein E, Winner B, Wegner M, Masliah E, Winkler J. Alpha-synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiology of Aging, 3/2014; epub, ahead of print.

Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Riek R, Winklder J, Gage FH, Winner B, Masliah E. Synaptic accumulation of oligomer prone a-synuclein exacerbates synatpci degeneration and neuronal loss in a transgenic mouse model. Brain, 2014; 137(5):1496-513. 

 

2013
Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm KJ, Winner B 2013. Alpha synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem 26;288(30):21742-54

Marxreiter F, Ettle B, May VE, Esmer H, Patrick C, Kragh CL, Klucken J, Winner B, Riess O, Winkler J, Masliah E, Nuber S 2013. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis 16;59C:38-51

 

2012
Winner B*, Regensburger M*, Schreglmann S. Boyer L, Prots I, Rockenstein E,
Mante M, Zhao C, Winkler J, Masliah E, Gage FH 2012. Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci 16906-16

Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K,
Roberts S, Patrick C, Winner B, Winkler J, Masliah E 2012. A-Synuclein induces
alterations in adult neurogenesis in Parkinson disease models via p53-mediated
repression of Notch1. J Biol Chem 14;287(38):31691-702

May VE, Nuber S, Marxreiter F, Riess O, Winner B, Winkler J 2012. Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein. Neurosci 2012;11;222:343-55

Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE,
Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ,
Farrer MJ, Melrose HL 2012. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor coordination behaviors.
Mol Neurodegen 30;7:25

Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD Jr,
Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S 2012. Gene expression
profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator
of adult hippocampal neurogenesis. J Neurosci 7;32(10):3376-87

 

2011
Winner B, Jappelli R, Maji SK, Desplats P, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH and Riek R 2011. In vivo demonstration that a-synuclein oligomers are toxic. PNAS 108(10):4194-9

Winner B, Kohl Z, Gage FH 2011. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci 33(6):1139-51

Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH 2011. Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis 41(3):706-16

 

2010
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. 2010. Mechanisms underlying inflammation in neurodegeneration. Cell 140:918-34

Marchetto MC, Winner B, Gage FH. 2010. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet 19:R71-6

 

2009
Marxreiter F, Nuber S, Kandasamy M, Klucken J, Aigner R, Riess O, Winkler J, Winner B. 2009. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur J Neurosci 29:879-90

Saijo K, Winner B, Carson CT, Collier JG, Boyer L, et al. 2009. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137:47-59

 

2008 and older
Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, et al. 2008. Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiol Aging 29:913-25

Hehr U, Bauer P, Winner B, Schule R, Olmez A, et al. 2007. Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. Ann Neurol 62:656-65

Winner B, Lie DC, Rockenstein E, Aigner R, Aigner L, et al. 2004. Human wild-type alpha-synuclein impairs neurogenesis. J Neuropathol Exp Neurol 63:1155-66

Winner B, Uyanik G, Gross C, Lange M, Schulte-Mattler W, et al. 2004b. Clinical progression and genetic analysis in hereditary spastic paraplegia with thin corpus callosum in spastic gait gene 11 (SPG11). Arch Neurol 61:117-21

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Dr. Katrin Faber
Anne Reichel
Bianca Meyerhöfer-Klee

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