Head of Department:
Prof. Dr. med. André Reis


Titze J. Interstitial fluid homeostasis and pressure: news from the black box. Kidney Int. 2013 Nov;84(5):869-71. doi: 10.1038/ki.2013.287.

Titze J, Dahlmann A, Lerchl K, Kopp C, Rakova N, Schröder A, Luft FC. Spooky sodium balance. Kidney Int. 2013 Oct 9. doi: 10.1038/ki.2013.367. [Epub ahead of print]

Wiig H, Schröder A, Neuhofer W, Jantsch J, Kopp C, Karlsen TV, Boschmann M, Goss J, Bry M, Rakova N, Dahlmann A, Brenner S, Tenstad O, Nurmi H, Mervaala E, Wagner H, Beck FX, Müller DN, Kerjaschki D, Luft FC, Harrison DG, Alitalo K, Titze J. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest. 2013 Jul 1;123(7):2803-15. doi: 10.1172/JCI60113. Epub 2013 Jun 3.

Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013 Apr 25;496(7446):518-22. doi: 10.1038/nature11868. Epub 2013 Mar 6.

Helle F, Karlsen TV, Tenstad O, Titze J, Wiig H. High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels.  Acta Physiol (Oxf). 2013; 207(3):577-81

Kopp C, Linz P, Dahlmann A, Hammon M, Jantsch J, Müller DN, Schmieder RE, Cavallaro A, Eckardt KU, Uder M, Luft FC, Titze J. 23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients. Hypertension. 2013 Mar;61(3):635-40. doi: 10.1161/HYPERTENSIONAHA.111.00566. Epub 2013 Jan 21.

Rakova N, Jüttner K, Dahlmann A, Schröder A, Linz P, Kopp C, Rauh M, Goller U, Beck L, Agureev A, Vassilieva G, Lenkova L, Johannes B, Wabel P, Moissl U, Vienken J, Gerzer R, Eckardt KU, Müller DN, Kirsch K, Morukov B, Luft FC, Titze J. Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance. Cell Metab. 2013 Jan 8;17(1):125-31. doi: 10.1016/j.cmet.2012.11.013.


Kopp C, Linz P, Hammon M, Schöfl C, Grauer M, Eckardt KU, Cavallaro A, Uder M, Luft FC, Titze J. Seeing the sodium in a patient with hypernatremia. Kidney Int. 2012 Dec;82(12):1343-4. doi: 10.1038/ki.2012.314.

Harrison DG, Marvar PJ, Titze JM. Vascular inflammatory cells in hypertension. Front Physiol. 2012 May 7;3:128. doi: 10.3389/fphys.2012.00128. eCollection 2012.

Kopp C, Linz P, Wachsmuth L, Dahlmann A, Horbach T, Schöfl C, Renz W, Santoro D, Niendorf T, Müller DN, Neininger M, Cavallaro A, Eckardt KU, Schmieder RE, Luft FC, Uder M, Titze J. (23)Na magnetic resonance imaging of tissue sodium. Hypertension. 2012 Jan;59(1):167-72. doi: 10.1161/HYPERTENSION. AHA.111.183517. Epub 2011 Dec 5.

Slagman MC, Kwakernaak AJ, Yazdani S, Laverman GD, van den Born J, Titze J, Navis G. Vascular endothelial growth factor C levels are modulated by dietary salt intake in proteinuric chronic kidney disease patients and in healthy subjects. Nephrol Dial Transplant. 2012 Mar;27(3):978-82. doi: 10.1093/ndt/gfr402. Epub 2011 Jul 21.


Titze J, Machnik A. Sodium sensing in the interstitium and relationship to hypertension. Curr Opin Nephrol Hypertens. 2010 Jul;19(4):385-92. doi: 10.1097/MNH.0b013e32833aeb3b. Review.

Machnik A, Dahlmann A, Kopp C, Goss J, Wagner H, van Rooijen N, Eckardt KU, Müller DN, Park JK, Luft FC, Kerjaschki D, Titze J. Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats. Hypertension. 2010 Mar;55(3):755-61. doi: 10.1161/HYPERTENSIONAHA.109.143339. Epub 2010 Feb 8.


Titze J. Water-free sodium accumulation. Semin Dial. 2009 May-Jun;22(3):253-5. doi: 10.1111/j.1525-139X.2009.00569.x. Review.

Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 2009 May;15(5):545-52. doi: 10.1038/nm.1960. Epub 2009 May 3.

Titze J, Ritz E. Salt and its effect on blood pressure and target organ damage: new pieces in an old puzzle. J Nephrol. 2009 Mar-Apr;22(2):177-89. Review.

Heer M, Frings-Meuthen P, Titze J, Boschmann M, Frisch S, Baecker N, Beck L. Increasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differently. Br J Nutr. 2009 May;101(9):1286-94. doi: 10.1017/S0007114508088041.

2008 & older

Ziomber A, Machnik A, Dahlmann A, Dietsch P, Beck FX, Wagner H, Hilgers KF, Luft FC, Eckardt KU, Titze J. Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Am J Physiol Renal Physiol. 2008 Dec;295(6):F1752-63. doi: 10.1152/ajprenal.00531.2007. Epub 2008 Oct 8.

Gratze P, Dechend R, Stocker C, Park JK, Feldt S, Shagdarsuren E, Wellner M, Gueler F, Rong S, Gross V, Obst M, Plehm R, Alenina N, Zenclussen A, Titze J, Small K, Yokota Y, Zenke M, Luft FC, Muller DN. Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension. Circulation. 2008 May 20;117(20):2645-56. doi: 10.1161/CIRCULATIONAHA.107.760116. Epub 2008 May 12.

Titze J. Water-free Na+ retention: interaction with hypertension and tissue hydration. Blood Purif. 2008;26(1):95-9. doi: 10.1159/000110573. Epub 2008 Jan 10. Review.

Schafflhuber M, Volpi N, Dahlmann A, Hilgers KF, Maccari F, Dietsch P, Wagner H, Luft FC, Eckardt KU, Titze J. Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol. 2007 May;292(5):F1490-500. Epub 2007 Jan 23.

Engeli S, Boschmann M, Frings P, Beck L, Janke J, Titze J, Luft FC, Heer M, Jordan J. Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue. Hypertension. 2006 Dec;48(6):1103-8. Epub 2006 Oct 23.

Titze J. Bone mineral content and blood pressure: What is the pathophysiologic link? Am J Hypertens. 2006 Aug;19(8):877-8. No abstract available. Erratum in: Am J Hypertens. 2006 Aug;19(8):876.

Titze J, Luft FC, Bauer K, Dietsch P, Lang R, Veelken R, Wagner H, Eckardt KU, Hilgers KF. Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats. Hypertension. 2006 Jun;47(6):1101-7. Epub 2006 Apr 24.

Titze J, Bauer K, Schafflhuber M, Dietsch P, Lang R, Schwind KH, Luft FC, Eckardt KU, Hilgers KF. Internal sodium balance in DOCA-salt rats: a body composition study. Am J Physiol Renal Physiol. 2005 Oct;289(4):F793-802. Epub 2005 May 24. Erratum in: Am J Physiol Renal Physiol. 2006 Feb;290(2):F561-2.

Volpi N, Maccari F, Titze J. Simultaneous detection of submicrogram quantities of hyaluronic acid and dermatan sulfate on agarose-gel by sequential staining with toluidine blue and Stains-All. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 5;820(1):131-5. Epub 2005 Apr 18.

Titze J, Rittweger J, Dietsch P, Krause H, Schwind KH, Engelke K, Lang R, Kirsch KA, Luft FC, Hilgers KF. Hypertension, sodium retention, calcium excretion and osteopenia in Dahl rats. J Hypertens. 2004 Apr;22(4):803-10.

Titze J, Shakibaei M, Schafflhuber M, Schulze-Tanzil G, Porst M, Schwind KH, Dietsch P, Hilgers KF. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H203-8. Epub 2004 Feb 19. Erratum in: Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1433.

Titze J, Lang R, Ilies C, Schwind KH, Kirsch KA, Dietsch P, Luft FC, Hilgers KF. Osmotically inactive skin Na+ storage in rats. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1108-17. Epub 2003 Jul 29.

Titze J, Schneider M, Krause H, Jacobi J, Stolte M, Linke RP, Rupprecht HD. Diarrhea, nephrotic syndrome and hidradenitis suppurativa: an unusual case. Nephrol Dial Transplant. 2003 Jan;18(1):192-4. No abstract available.

Titze J, Maillet A, Lang R, Gunga HC, Johannes B, Gauquelin-Koch G, Kihm E, Larina I, Gharib C, Kirsch KA. Long-term sodium balance in humans in a terrestrial space station simulation study. Am J Kidney Dis. 2002 Sep;40(3):508-16.

Titze J, Krause H, Hecht H, Dietsch P, Rittweger J, Lang R, Kirsch KA, Hilgers KF. Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model. Am J Physiol Renal Physiol. 2002 Jul;283(1):F134-41.

IZKF Administrative Office

Dr. Katrin Faber (46841)
Anne Reichel (46843)
Bianca Meyerhöfer-Klee (46753)
Kathrin Neufang (46842)


Phone: +49 9131 85-46842
Fax: +49 9131 85-35903

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