IZKF-Project J58


Head of Department:
Prof. Dr. med. André Reis

Counteracting Wnt signaling

Axin and conductin are paralogous negative regulators of Wnt/ß-catenin signaling. Polymerisation, which is essential for axin activity, is inhibited in conductin by its RGS domain making it less active than axin. Conductin polymerisation could be enforced by a RGS-binding protein or by introducing the axin RGS domain in conductin thereby increasing degradation of ß-catenin. We will study how conductin polymerisation is regulated with the goal to inhibit ß-catenin driven colorectal cancer growth.

Dr. Dominic Bernkopf
phone: +49 9131 85-29122
fax: +49 9131 85-29111
e-mail: dominic.bernkopf@fau.de
business card

01.09.2016 - 28.02.2019


Project Manager

Dr. Dominic Bernkopf

Chair of Experimental Medicine II

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