Axin and conductin are paralogous negative regulators of Wnt/ß-catenin signaling. Polymerisation, which is essential for axin activity, is inhibited in conductin by its RGS domain making it less active than axin. Conductin polymerisation could be enforced by a RGS-binding protein or by introducing the axin RGS domain in conductin thereby increasing degradation of ß-catenin. We will study how conductin polymerisation is regulated with the goal to inhibit ß-catenin driven colorectal cancer growth.
Chair of Experimental Medicine II