Hepatocellular carcinoma (HCC) is a deadly cancer with poorly understood pathological features. It is known that several microRNAs are dysregulated in HCC. We found that a mostly unknown microRNA in cancer - miR-188-5p - is down-regulated in HCC cells and first experiments reveal potent tumorsuppressive functions of miR-188-5p. Therefore, in this project, we want to explore the role of miR-188-5p dysregulation and function in HCC development and progression and its potential therapeutic benefit.
Institute of Biochemistry