IZKF-Project J47

IZKF

Head of Department:
Prof. Dr. med. André Reis

Post-transcriptional regulation by Hoxa9

The oncogene Hoxa9 contributes to post-transcriptional regulation by interaction with the RNA export and protein synthesis regulator eIF4e. To date, target genes of this interaction have not been identified. Therefore, we aim to identify post-transcriptional targets of Hoxa9 and eIF4e by RNA immunoprecipitation. Moreover, analyses of altered RNA-export will be performed as functional validation. In summary, this study will help to clarify the contribution of Hoxa9 to leukemogenesis and provide a solid basis to uncover novel therapeutically relevant targets.

Dr. Christian Bach
phone: +49 9131 85-33092
DECT: +49 9131 85-43195
fax: +49 9131 85-33399
e-mail: christian.bach@uk-erlangen.de
business card
 
Term

01.03.2015 - 31.08.2017

Project Manager

Dr. Christian Bach

Department of Medicine 5

 
 
 
 
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Summary