The oncogene Hoxa9 contributes to post-transcriptional regulation by interaction with the RNA export and protein synthesis regulator eIF4e. To date, target genes of this interaction have not been identified. Therefore, we aim to identify post-transcriptional targets of Hoxa9 and eIF4e by RNA immunoprecipitation. Moreover, analyses of altered RNA-export will be performed as functional validation. In summary, this study will help to clarify the contribution of Hoxa9 to leukemogenesis and provide a solid basis to uncover novel therapeutically relevant targets.
01.03.2015 - 31.08.2017
Department of Medicine 5