IZKF-Project J52

IZKF

Head of Department:
Prof. Dr. med. André Reis

Neuronal proliferation in SPG11-HSP

Mutations in SPG11 are the most frequent cause of complicated hereditary spastic paraplegia (HSP). Neurons differentiated from SPG11-patient-iPSC show reduced neurite growth. Our preliminary experiments additionally indicate a reduced proliferation of neural progenitor cells in SPG11-HSP. In the proposed project, this proliferation deficit will be comprehensively characterized in order to identify underlying molecular pathways and potential targets for interventions.

Dr. Martin Regensburger
DECT: +49 9131 85-44798
e-mail: martin.regensburger@uk-erlangen.de
business card
 
Term

01.11.2015 - 30.04.2018

Project Manager

Dr. Martin Regensburger

Department of Neurology

 
 
 
 
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Summary