Mutations in SPG11 are the most frequent cause of complicated hereditary spastic paraplegia (HSP). Neurons differentiated from SPG11-patient-iPSC show reduced neurite growth. Our preliminary experiments additionally indicate a reduced proliferation of neural progenitor cells in SPG11-HSP. In the proposed project, this proliferation deficit will be comprehensively characterized in order to identify underlying molecular pathways and potential targets for interventions.
01.11.2015 - 30.04.2018
Department of Neurology