Transcription factor Sox10 plays essential roles in myelinating glia and its loss causes severe demyelinating conditions. Downstream targets and interaction partners in the nervous system are only partly known. Recent transcriptome and ChIP-Seq data identified transcription factor Zfp276 as a potential Sox10 target. Its expression overlapped strongly with Sox10. I plan to verify the effector-target relationship between Sox10 and Zfp276 and to characterize the functions of Zfp276 as a mediator of Sox10-dependent regulation of glial differentiation and myelin maintenance.
01.04.2015 - 30.09.2017
Institute of Biochemistry