DUX4 is a developmental transcription factor exclusively expressed in early embryogenesis. Aberrant expression of DUX4 in muscle cells is the cause of Facioscapulohumeral muscular dystrophy. Preliminary data showed, that DUX4 expression is also induced upon herpesviral infection, leading to the upregulation of hundreds of DUX4 target genes. This proposal aims at identifying the mechanism of herpesviral DUX4 induction and the role of DUX4 and its target genes on viral replication.
01.01.2017 - 30.06.2019
Institute of Clinical and Molecular Virology