IZKF-Project J57

IZKF

Head of Department:
Prof. Dr. med. André Reis

Herpesviruses and DUX4

DUX4 is a developmental transcription factor exclusively expressed in early embryogenesis. Aberrant expression of DUX4 in muscle cells is the cause of Facioscapulohumeral muscular dystrophy. Preliminary data showed, that DUX4 expression is also induced upon herpesviral infection, leading to the upregulation of hundreds of DUX4 target genes. This proposal aims at identifying the mechanism of herpesviral DUX4 induction and the role of DUX4 and its target genes on viral replication.

Dr. Florian Full
phone: +49 9131 85-26494
fax: +49 9131 85-26493
business card
 
Term

01.01.2017 - 30.06.2019

Project Manager

Dr. Florian Full

Institute of Clinical and Molecular Virology

 
 
 
 
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Summary