Our preliminary data show that recognition of apoptotic cells (ACs) by macrophages dramatically affects chromatin remodelling processes within these phagocytes, resulting in an anti-inflammatory macrophage phenotype. We hypothesize that these events essentially contribute to the non-immunogenic clearance of dying cells. In the proposed project, we plan to dissect the underlying molecular mechanisms and determine the role of these pathway during the the resolution of injury-induced inflammation.
01.01.2017 - 30.06.2019
Department of Medicine 3