IBD in humans is combined with a risk for developing CAC. Previously, we could identify Th9 cells as drivers of IBD and therefore we will analyse the role of IL-9 in CAC. The functional role will be investigated with specific KO mice for IL-9, IL-9R and PU.1 in an experimental CAC model as well as in tumor patients. The aim is to understand the IL-9 driven induction of CAC and to develop a therapeutical concept for CAC.
16.10.2015 - 15.04.2018
Department of Medicine 1