Chromatin-based modifications of herpesviral genomes play a crucial role in dictating the outcome of infection. Host cell multiprotein complexes like the Polycomb repressive complex 2 (PRC2) have been identified as regulators of viral gene expression on the epigenetic level. This proposal aims at investigating the role of the HCMV regulatory protein IE2p86 in modulating the function of PRC2 during lytic as well as latent HCMV infection by interacting with the core component EED.
01.01.2015 - 30.06.2018
Institute of Clinical and Molecular Virology