IZKF-Project J45

IZKF

Head of Department:
Prof. Dr. med. André Reis

Modulation of PRC2 activity by HCMV IE2

Chromatin-based modifications of herpesviral genomes play a crucial role in dictating the outcome of infection. Host cell multiprotein complexes like the Polycomb repressive complex 2 (PRC2) have been identified as regulators of viral gene expression on the epigenetic level. This proposal aims at investigating the role of the HCMV regulatory protein IE2p86 in modulating the function of PRC2 during lytic as well as latent HCMV infection by interacting with the core component EED. 

Dr. Nina Reuter
phone: +49 9131 85-22100
fax: +49 9131 85-26493
e-mail: nina.tavalai@viro.med.uni-erlangen.de
business card
 
Term

01.01.2015 - 30.06.2018

Project Manager

Dr. Nina Reuter

Institute of Clinical and Molecular Virology

 
 
 
 
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Summary