In spite of clear evidence of its importance a basic feature of renal innervation - the regulation of sympathetic activity by afferent renal nerves - is not yet understood. It is particularly unclear whether renal afferents, i.e. the dorsal root ganglion neurons with renal projections, stimulate or inhibit sympathetic activity. We want to demonstrate in a model of experimental hypertension that afferent renal nerve activity acts rather sympathoinhibitory but not sympathoexcitatory.
Department of Medicine 4
Department of Nephropathology