IZKF-Project F5

IZKF

Head of Department:
Prof. Dr. med. André Reis

The Role of ANO1 in Polycystic Kidney Disease

In Polycystic Kidney Diseases (PKD) continuous growth of renal cysts due to proliferation and fluid secretion causes renal failure. Although the underlying mechanisms remain incompletely understood, they appear to be related to the primary cilium. We aim to analyze the functional role of the calcium-activated chloride channel ANO1 for progression of PKD in a PKD mouse model and in PKD cells and to study its impact on ciliary calcium homeostasis and cell proliferation.

Dr. Björn Buchholz
phone: +49 9131 85-39002
fax: +49 9131 85-39209
e-mail: bjoern.buchholz@uk-erlangen.de
business card
 
Term

01.07.2016 - 31.12.2018

Project Manager

Dr. Björn Buchholz

Institute of Human Genetics

 
 
 
 
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Summary