IZKF-Project D28

IZKF

Head of Department:
Prof. Dr. med. André Reis

SPARCL1 in colorectal carcinoma

We demonstrated tumor microenvironment (TME)-dependent heterogeneity of tumor endothelial cells in colorectal carcinoma (CRC) and obtained evidence that SPARCL1 may act as a TME-dependent endothelial cell-secreted antagonist of tumor growth and regulatory molecule of blood vessel homeostasis. The project investigates function and underlying mechanisms of SPARCL1 in both processes. Long-term objective is the development of a SPARCL1-based treatment approach to suppress metastases in CRC patients.

Prof. Dr. Dr. Michael Stürzl
phone: +49 9131 85-39520
fax: +49 9131 85-39523
e-mail: michael.stuerzl@uk-erlangen.de
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PD Dr. Elisabeth Naschberger
phone: +49 9131 85-39141
fax: +49 9131 85-32077
e-mail: elisabeth.naschberger@uk-erlangen.de
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Term

01.02.2016 - 31.07.2018

Project Manager

Prof. Dr. Michael Stürzl

Department of Surgery


PD Dr. Elisabeth Naschberger

Department of Surgery

 
 
 
 
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Summary