IZKF-Project D27


Head of Department:
Prof. Dr. med. André Reis

2-HG as an Onco- and Immunometabolite in AML

Metabolic alterations represent a hallmark of cancer and promote malignant features. Increasing evidence suggests that metabolic communication between tumor cells and the immune system contributes to immune escape. Elevated levels of the metabolite 2-hydroxyglutarate (2-HG) were observed in AML patients and represent a negative prognostic marker. We want to (A) identify novel (targetable) pathways driving 2-HG accumulation and to (B) investigate whether 2-HG exerts immune modulating effects.

Prof. Dr. med. Dimitrios Mougiakakos
e-mail: dimitrios.mougiakakos@uk-erlangen.de
business card

01.07.2016 - 31.12.2018

Project Manager

Prof. Dr. Dimitrios Mougiakakos

Medizinische Klinik 5

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