Metabolic alterations represent a hallmark of cancer and promote malignant features. Increasing evidence suggests that metabolic communication between tumor cells and the immune system contributes to immune escape. Elevated levels of the metabolite 2-hydroxyglutarate (2-HG) were observed in AML patients and represent a negative prognostic marker. We want to (A) identify novel (targetable) pathways driving 2-HG accumulation and to (B) investigate whether 2-HG exerts immune modulating effects.
Medizinische Klinik 5