Triple negative breast cancer (TNBC) is characterized by aggressive growth, mainly affects younger women and is difficult to treat. Interestingly, the density of immune cell infiltrates in the primary tumor positively correlates with outcome. However, it is so far unknown which antigens are targeted by the tumor infiltrating T-cells. The aim of this project is to identify the targets of tumor infiltrating T-cells in TNBC with main focus on tumor-specific mutations.
Department of Medicine 5
Department of Obstetrics and Gynaecology