In cholestatic patients with chronic pruritus we previously found elevated serum levels of lysophosphatidic acid (LPA). The aim of this translational project is to unravel the molecular mechanisms of LPA in cellular assays and to understand the interaction with substances known to cause itch. This will be validated in an animal model and tested in preclinical human studies. Unravelling this pathway could open new avenues for causal anti-pruritic treatment strategies.
Department of Medicine 1
Institute of Physiology and Pathophysiology