IZKF-Project E27

IZKF

Head of Department:
Prof. Dr. med. André Reis

LPA-induced pruritus of cholestasis

In cholestatic patients with chronic pruritus we previously found elevated serum levels of lysophosphatidic acid (LPA). The aim of this translational project is to unravel the molecular mechanisms of LPA in cellular assays and to understand the interaction with substances known to cause itch. This will be validated in an animal model and tested in preclinical human studies. Unravelling this pathway could open new avenues for causal anti-pruritic treatment strategies.

Dr. Andreas E. Kremer
phone: +49 9131 85-35000
e-mail: andreas.kremer@uk-erlangen.de
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Prof. Michael Fischer
phone: +49 9131 85-29302
fax: +49 9131 85-22497
e-mail: fischer@physiologie1.uni-erlangen.de
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Term

01.03.2016 - 31.08.2018

Project Manager

Dr. Andreas Kremer

Department of Medicine 1


Prof. Dr. Michael Fischer

Institute of Physiology and Pathophysiology

 
 
 
 
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Summary