Drug addiction is a major psychiatric disorder. In the first Swiprosin-1/EFhd2 knock out model we found that EFhd2 works as resilience factor against addiction. We will now investigate how and where in the brain EFhd2 regulates the reinforcing effects of alcohol and methamphetamine, by controlling neurochemical, electrophysiological, and gene expression effects during addiction establishment. These insights will allow for a better understanding of resilience mechanisms against drug addiction.
Department of Psychiatry and Psychotherapy
Institute of Physiology and Pathophysiology
Department of Molecular Immunology