Synucleinopathies are age-associated neurodegenerative disorders characterized by the intracellular accumulation of alpha-synuclein (aSyn) aggregates. This project will address the currently unresolved question of how ageing accelerates aSyn toxicity and cerebral spreading. Specifically, it will investigate whether modulation of autophagy by the ageing-associated FoxO-pathway affects exosomal release of aSyn, transcellular propagation, and acceleration of aSyn-toxicity.
Institute of Biochemistry
Department of Molecular Neurology