IZKF-Project E21

IZKF

Head of Department:
Prof. Dr. med. André Reis

FoxOs and alpha-Synuclein pathology

Synucleinopathies are age-associated neurodegenerative disorders characterized by the intracellular accumulation of alpha-synuclein (aSyn) aggregates. This project will address the currently unresolved question of how ageing accelerates aSyn toxicity and cerebral spreading. Specifically, it will investigate whether modulation of autophagy by the ageing-associated FoxO-pathway affects exosomal release of aSyn, transcellular propagation, and acceleration of aSyn-toxicity.

Prof. Dr. Dieter Chichung Lie
phone: +49 9131 85-24622
e-mail: chi.lie@fau.de
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Prof. Dr. Jochen Klucken
phone: +49 9131 85-39324
DECT: +49 9131 85-44259
fax: +49 9131 85-34672
e-mail: jochen.klucken@uk-erlangen.de
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Term

01.05.2016 - 30.04.2019

Project Manager

Prof. Dr. Dieter Chichung Lie

Institute of Biochemistry


Prof. Dr. Jochen Klucken

Department of Molecular Neurology

 
 
 
 
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Summary