Chronic pruritus is an agonizing symptom accompanying many dermatological and systemic disorders. The aim of this project is to identify pruritogens in plasma of patient suffering from chronic pruritus, to unravel specific NaV channel subtypes that define itch pathways, and to identify and characterize novel gene products that predispose to or protect from itch by in silico genetic mapping in mice. These results may pave the way towards novel treatment targets for this dreadful symptom.
Department of Medicine 1
Department of Anaesthesiology