Sensory organs need tailor-made signal transduction pathways. Pre-synaptic glutamate- and endocannabinoidreceptors regulate activity and survival of sensory neurons via inhibitory feedback loops. While pre-synaptic inhibition in photoreceptors of the retina is described in detail, corresponding molecular mechanisms in hair-cells of the cochlea are largely unknown. Here, we will investigate pre-synaptic receptor expression in hair-cells and elucidate their regulation by interacting proteins.
Institute of Biochemistry