The aim of this project is to elucidate the function of CD83 expressed on Tregs. Recently we reported that after activation Tregs rapidly upregulate CD83 expression, providing a new phenotypic marker for activated Tregs. However, the functional importance of this expression is completely unknown. Using our recently generated conditional KO animals, whereby CD83 expression is exclusively deleted on Tregs we aim to elucidated the role of CD83 for activation and suppressive capacity of Tregs.
Department of Immune Modulation