IZKF-Project A70

IZKF

Head of Department:
Prof. Dr. med. André Reis

DUB-inhibitors and HIV-1

We could show that certain deubiquitinating enzymes (DUBs) play an essential role in HIV-1 replication, at least by regulating Gag processing, virus infectivity, and entry of Gag into the MHC-I pathway. DUB-inhibitors offer a new way for antiretroviral therapy as they (1) target genetically stable cellular factors, (2) interfere with virus spread, and (3) have the potential to improve immune recognition of HIV-1+-cells. 

Prof. Dr. rer. nat. Ulrich Schubert
phone: +49 9131 85-26478
e-mail: ulrich.schubert@viro.med.uni-erlangen.de
business card
 
Term

01.07.2016 - 31.12.2018

Project Manager

Prof. Dr. Ulrich Schubert

Institute of Clinical and Molecular Virology

 
 
 
 
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Summary