IZKF-Project A69

IZKF

Head of Department:
Prof. Dr. med. André Reis

ATM/DDR in infection and inflammation

The DNA-damage response (DDR) requires the kinase ATM and is essential for the integrity of the host genome. We observed activation of the ATM kinase pathway in Toll-like receptor (TLR)-stimulated macrophages and a modulation of the inflammatory response by ATM-inhibition. We propose now detailed studies to elucidate  the molecular mechanisms and the consequences of ATM/DDR activation for the host response, protection and immunopathology during infection.

Prof. Dr. med. Roland Lang
phone: +49 9131 85-22979
DECT: +49 9131 85-46904
fax: +49 9131 85-22573
e-mail: roland.lang@uk-erlangen.de
business card
 
Term

01.07.2016 - 31.12.2018

Project Manager

Prof. Dr. Roland Lang

Institute of Microbiology

 
 
 
 
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Summary