LINE-1 retroelements have been shown to cause mutations resulting in various genetic disorders. It is therefore essential to control their replication to maintain genome integrity. A strong block to retroviral infection is mediated by TRIM5a. In first experiments, we found that TRIM5a also inhibits the retrotransposition of LINE-1. Thus, this study will analyze this novel function of TRIM5a and its contribution to genome stability by blocking the replication of endogenous retroelements.
Institute of Clinical and Molecular Virology