IZKF-Project A67

IZKF

Head of Department:
Prof. Dr. med. André Reis

TRIM5alpha blocks LINE-1 retroelements

LINE-1 retroelements have been shown to cause mutations resulting in various genetic disorders. It is therefore essential to control their replication to maintain genome integrity. A strong block to retroviral infection is mediated by TRIM5a. In first experiments, we found that TRIM5a also inhibits the retrotransposition of LINE-1. Thus, this study will analyze this novel function of TRIM5a and its contribution to genome stability by blocking the replication of endogenous retroelements.

 

Prof. Dr. rer. nat. Thomas Gramberg
phone: +49 9131 85-36481
e-mail: thomas.gramberg@fau.de
business card
 
Term

01.02.2016 - 31.07.2018

Project Manager

Prof. Dr. Thomas Gramberg

Institute of Clinical and Molecular Virology

 
 
 
 
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Summary