IZKF-Project A63

IZKF

Head of Department:
Prof. Dr. med. André Reis

Mechanisms of antimicrobial defense by TNF

Tumor necrosis factor (TNF)-deficient mice fail to control the intracellular protozoan pathogen Leishmania major, despite an intact IFN-γ (Th1) immune response and a sustained expression of type 2 nitric oxide synthase (NOS2) mRNA and protein, which is the key antileishmanial effector pathway. Here, we will test the hypothesis that TNF conveys protection by alternative mechanisms including the induction of NOS2 cofactors and the downregulation of arginine-metabolizing enzymes such as arginase 1.

Prof. Dr. Christian Bogdan
phone: +49 9131 85-22551
fax: +49 9131 85-1001
e-mail: christian.bogdan@uk-erlangen.de
business card
 
Term

01.07.2016 - 31.12.2018

01.02.2016 bis 31.07.2018

Project Manager

Prof. Dr. Christian Bogdan

Institute of Clinical Microbiology

 
 
 
 
Please insert your name and correct email addresses!
X zum Schließen

Summary