Genetic and genomic studies for complex traits and clinical studies require high quality DNA-samples of probands as well as a rigorous and reliable handling and tracking of large numbers of samples. Starting in 2009, the IZKF core facility Z4 “DNA-Extraktionsplattform (Biobank)” was established offering quality controlled DNA-extraction from blood samples and other body fluids, their handling and aliquoting as well as their long-term archiving. The Core Unit has two large scale semi-automatic DNA-extraction platforms, a chemagic magnetic separation module I(Perkin Elmer) and an Autopure LS (Qiagen) and has a capacity of up to 10,000 samples/year. Both platforms yield high quality DNA samples suitable for all downstream applications such as PCR, SNP genotyping, microarray applications and next-generation sequencing. Part of the instrumentation was co-funded by the Erlangen University Comprehensive Cancer Centre. After conclusion of the IZKF funding in 2013 the core facility continues to offer its services financed through user fees.